Other indications

With its anti-adhesive properties, sevuparin may be useful in several other clinical indications where microvascular obstructions are the underlying cause.

Learn how sevuparin works

Severe malaria

With life-saving potential in severe malaria. Our lead candidate, sevuparin, also targets several critical stages important in the development of severe malaria. Today, even with the best available treatment, the mortality from severe Plasmodium falciparum malaria remains high. However, we believe that based on its mechanism of action, quick onset of effect and excellent tolerability, that this new drug has the potential to save lives.

A clinical phase I/II study sponsored by Modus Therapeutics, concluded in 2014, demonstrated proof of concept of sevuparin in patients with uncomplicated malaria. Sevuparin was able to release parasite-infected red blood cells into circulation which could normalize a restricted blood flow, as well as to block parasitic which is important to reduce further parasite growth. Effects were detected just one hour after the start of sevuparin treatment and prior to those of the anti-parasitic drug the patient was also receiving. Those moments could be life-saving alongside an anti-malarial drug. Sevuparin is ready to enter a phase II in patients with severe malaria.

 

Additional indication

Sevuparin may also be useful in several other rare clinical indications where microvascular obstructions are the underlying cause.