SEVUPARIN IN ACTION
Sevuparin, a novel polysaccharide, interacts with multiple targets during a vaso-occlusive crisis. These interactions cause the release of blood components bound to each other and bound to the endothelial wall, preventing further occlusions from occurring.
Sevuparin blocks sickle blood cell adhesion and sickle-leucocyte rolling on immobilized L-selectin in a dose dependent manner. British Journal of Haematology. May 2018
Inhibition of merozoite invasion and transient de-sequestration by sevuparin in humans with Plasmodium falciparum malaria. PLoS One. December 2017.
Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes. PLoS One. March 2017
Sevuparin binds to multiple adhesive ligands and reduces sickle red blood cell-induced vaso-occlusion. British Journal of Haematology. December 2016.