Kallelse till årsstämma i Modus Therapeutics Holding AB

STOCKHOLM, SWEDEN – 20 April 2021.

Aktieägarna i Modus Therapeutics Holding AB, 556851-9523, kallas härmed till årsstämma måndagen den 3 maj 2021. Med anledning av den pågående pandemin kommer årsstämman, med stöd av tillfälliga lagregler, att genomföras genom enbart förhandsröstning (poströstning). Någon årsstämma med möjlighet att närvara personligen eller genom ombud kommer inte att äga rum. Information om de av årsstämman fattade besluten offentliggörs den 3 maj 2021 så snart utfallet av förhandsröstningen är slutligt sammanställt

For more details, please follow the following documents:

Formulär för poströstning

For further information, please contact:

John Öhd, CEO, Modus Therapeutics:

Tel: +46 70 766 8097
E-mail: john.ohd@modustx.com

Nathaniel Dahan or David Dible, Citigate Dewe Rogerson

Tel: +44 20 7638 9571
E-mail: modustx@citigatedewerogerson.com



About Modus Therapeutics AB

Modus Therapeutics is a Swedish biotech company developing sevuparin with a focus on diseases with high unmet medical need. The Company’s near-term focus is to develop sevuparin for patients with sepsis/septic shock, a severe and often fatal condition. Modus is backed by KDev Investments AB, (part of Karolinska Development AB (Nasdaq Stockholm: KDEV) and Rosetta Capital), The Foundation for Baltic and European Studies (Östersjöstiftelsen) and Praktikerinvest AB.

About sevuparin

Sevuparin is a clinical stage, innovative proprietary polysaccharide drug with a multimodal mechanism of action, including anti-inflammatory, anti-adhesive and anti-aggregate effects.  Sevuparin is a heparinoid with markedly attenuated anti-coagulation features that allows severalfold higher doses to be given, compared to regular heparinoids, without the associated risk for bleeding side-effects. Two routes of administration of sevuparin are currently being tested – an IV formulation for in-patient administration and a subcutaneous formulation that allows ambulatory and home care administration.

About severe systemic inflammation

Severe systemic inflammation conditions (also known as systemic inflammatory response syndrome, SIRS) are feared complications of severe medical conditions such as infection, trauma, and major surgery. It is characterized by an uncontrolled systemic inflammatory response that can progress into shock and multi-organ failure. One such manifestation is septic shock, which is a leading cause of death in intensive care units worldwide, with mortality rates typically exceeding 30%.

In systemic inflammation reactions, vascular hyper-permeability caused by the inflammatory response, may cause significant endothelial damage, plasma leakage and excessive edema formation. The pulmonary circulation is particularly vulnerable leading to respiratory distress, and in time more advanced multi-organ damage ensues. Neutrophil granulocytes, releasing an array of potent inflammatory mediators exhibiting permeability–increasing properties, are critically involved in the capillary-alveolar barrier breakdown.

There is currently no pharmaceutical product available that can be specifically used to treat patients with uncontrolled systemic inflammation such as sepsis. The current standard of care for hospitalized patients relies on aggressive fluid therapy, vasopressors, oxygen, corticoid steroids and mechanical ventilation.