ACTION OF SEVUPARIN IN SEPTIC SHOCK
Sevuparin, a novel polysaccharide, acts by interfering with the harmful agents1 generated by white blood cells during systemic inflammation. This interference can break the molecular chain of events that lead to vascular damage and plasma leakage in patients with sepsis/septic shock and other conditions where systemic inflammation is involved.
Sevuparin directly binds and neutralizes agents released from damaged white blood cells that are known to threaten vascular integrity. This activity has been shown in pre-clinical animal models, where sevuparin has been effective in protecting the blood vessels and the lungs of mice.
1 Rasmuson et al, 2019